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KMID : 0380019940090040406
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Korean Journal of Biotechnology and Bioengineering
1994 Volume.9 No. 4 p.406 ~ p.411
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Citric Acid Production by Extractive Fermentation
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Abstract
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An extractive fermentation process was developed to produce citric acid from glucose. Citric acid is a strong inhibitor to this fermentation. A mixture of tertiary amine and oleyl alcohol was used to selectively extract citric acid from the fermentation broth, hence enhancing the productivity by over 200 %. Although the toxicity of the solvent was significant in the range of higher than 30% of amine, immobilization in polyurethane foam was useful to protect the cells from the toxicity of the solvent.
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